Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. Includes bibliographical references (pages 27-33).
Cyclic acid anhydrides are widely used in the chemical industry in the manufacture of polyester and alkyd resins and plasticizers and as epoxy resin hardeners. Acid anhydrides are irritants and are especially potent sensitizing agents. This document deals with the following anhydrides of concern: phthalic anhydride, trimellitic anhydride, maleic anhydride, hexahydrophthalic anhydride, methyl hexahydrophthalic anhydride, methyl tetrahydrophthalic anhydride, tetrahydrophthalic anhydride, tetrachlorophthalic anhydride, pyromellitic dianhydride, himic anhydride, succinic anhydride, dodecenylsuccinic anhydride, chlorendic anhydride, and tetrabromophthalic anydride. Chemical safety cards for several cyclic acid anhydrides, produced by the International Program on Chemical Safety (IPCS) are reproduced in this document--Publisher's description. Executive summary -- Identity and physical/chemical properties -- Analytical methods -- Sources of human exposure -- Environmental transport, distribution, and transformation -- Human exposure -- Comparative kinetics and metabolism in laboratory animals and humans -- Effects of laboratory mammals and in vitro test systems -- Effects on humans -- Evaluation of health effects -- Previous evaluations by inter-organization programme for the sound management of chemicals (IOMC) bodies.