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RECORD NUMBER: 78 OF 343

OLS Field Name OLS Field Data
Main Title Comparative potency approach for estimating the cancer risk associated with exposure to mixtures of polycyclic aromatic hydrocarbons (interim report final) {Microfiche}
Author Lewtas, Joellen
CORP Author ICF-Clement Associates, Fairfax, VA.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher ICF-Clement Associate for U.S. Environmental Protection Agency
Year Published 1988
Report Number EPA-68-02-4403; EPA/600/R-95/108
Stock Number PB95-252847
OCLC Number 49563266
Subjects Genetic toxicology--Technique
Additional Subjects Polychloric aromatic hydrocarbons ; Carcinogenesis ; Risk assessment ; Dose-response relationships ; Mathematical models ; Environmental health ; Biological effects ; Concentration(Composition) ; Occupational exposure ; Mixtures ; Potency estimate
Holdings
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Status
NTIS  PB95-252847 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 138 p. ; 28 cm.
Abstract
A relative potency approach was developed as a method for assessing the cancer risk of polycyclic aromatic hydrocarbons (PAHs) for which inadequate ingestion or inhalation bioassay data exist. This approach takes into account the differing potencies of carcinogenic PAHs rather than assuming that all carcinogenic PAHs are equivalent in potency to benzo(a)pyrene. A two-stage mathematical dose-response model is postulated that is consistent with the biological mechanisms of action of PAHs. The assumptions for using a two-stage model for PAH carcinogenesis are described and their experimental support presented.
Notes
"EPA 600/R-95/108."