Record Display for the EPA National Library Catalog

RECORD NUMBER: 179 OF 334

OLS Field Name OLS Field Data
Main Title Letter from Rhom and Haas Company to US EPA regarding Submission of Abstract and Summary Pages from Draft Epidemiology Study using Chloromethyl Ethers with Attachments.
CORP Author Rohm and Haas Co., Bristol, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 26 Jul 1990
Year Published 1990
Report Number FYI-OTS-0790-0776;
Stock Number OTS-0000776
Additional Subjects Respiratory system diseases ; Epidemiology ; Chloromethyl ethers ; Toxic substances ; Neoplasms ; Occupational exposure ; Lung cancer ; Diagnosis(Medicine) ; Carcinogens ; Induction ; Dose-response relationships ; Humans ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  OTS-0000776 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 07/09/2008
Collation 53p
Abstract
Lung cancers occurred at a higher rate among workers who had been potentially exposed in the past to chloromethyl-methyl- ether/bis-chloromethyl-ether than among unexposed workers at the same plant (RR 4.4, 95%Cl 1.8-10.9), or among an externalreference population (RR 4.4, 95%CI 5.5-10). The average age at diagnosis among the exposed was at least 10.5 years lower than among theunexposed. The predominantly small-cell cancers of the exposed were mostly oat-cell, a characteristic of lung cancers in groups exposed to CMME/BCME. There was a positive dose response. The mean time from first exposure to diagnosis was 13 years (95%CI 8-18 years). Dose and induction time were not associated. The rate for the exposed workers peaked somewhere between 7 and 13 years after the start-up of the process, and has declined since. It is impossible to say if the period of excess rate has passed completely, but there are indications that it is essentially over.