Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title DNA Replication - Damage from Environmental Carcinogens [electronic resource] /
Author Zhang, Huidong.
Publisher Springer Netherlands : Imprint: Springer,
Year Published 2015
Call Number QD433-436
ISBN 9789401772129
Subjects Life sciences. ; Toxicology. ; Nucleic acids. ; Cytology.
Internet Access
Description Access URL
Collation XI, 43 p. 4 illus., 1 illus. in color. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
DNA replication -- Disturbances of the DNA replication system -- Fate of DNA replisome upon encountering DNA damage -- External Causes for DNA Damage -- Effect of environmental carcinogens on cellular physiology -- Protocols for studies of bypass of DNA damage by DNA polymerase. This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.