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RECORD NUMBER: 137 OF 526

OLS Field Name OLS Field Data
Main Title Comparison of Biochemical Effects of Nitrogen Dioxide, Ozone and Their Combination in Mouse Lung. 1. Intermittent Exposures.
Author Mustafa, M. G. ; Elsayed, N. M. ; von Dohlen, F. M. ; Hassett, C. M. ; Postlehwait, E. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Los Angeles. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-600/J-84-016; EPA-R-806652;
Stock Number PB84-198340
Additional Subjects Toxicology ; Nitrogen dioxide ; Ozone ; Physiological effects ; Mice ; Exposure ; Comparison ; Lung ; Laboratory animals ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-198340 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 11p
Abstract
Swiss Webster mice were exposed to either 4.8 ppm (9024 micrograms/cu.m.) nitrogen dioxide (NO2), 0.45 ppm (882 micrograms/cu.m.) ozone (O3), or their combination intermittently (8 hr daily) for 7 days, and the effects were studied in the lung by a series of physical and biochemical parameters, including lung weight, DNA and protein contents, oxygen consumption, sulfhydryl metabolism, and activities of NADPH generating enzymes. The results show that exposure to NO2 caused relatively smaller changes than O3, and that the effect of each gas alone under the conditions of exposure was not significant for most of the parameters tested. However, when the two gases were combined, the exposure caused changes that were greater and significant. Statistical analysis of the data shows that the effects of combined exposure were more additive, i.e., they might be synergistic. The observations suggest that intermittent exposure to NO2 or O3 alone at the concentration used may not cause significant alterations in lung metabolism, but when the two gases are combined the alterations may become significant.