Record Display for the EPA National Library Catalog

RECORD NUMBER: 113 OF 526

OLS Field Name OLS Field Data
Main Title Biochemical Changes in Humans Upon Exposure to Nitrogen Dioxide While at Rest.
Author Chaney, Suzanne ; Blomquist, Wendy ; DeWitt, Paulett ; Muller, Keith ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-80-108;
Stock Number PB82-127473
Additional Subjects Nitrogen dioxide ; Humans ; Exposure ; Physiological effects ; Responses ; Air pollution ; Reprints ; Air pollution effects(Humans)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB82-127473 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract
The biochemical response to controlled exposures of nitrogen dioxide (NO2) was studied in 19 human subjects exposed to 0.2 ppm NO2 for 2 hr and compared to 15 control subjects exposed to filtered air for 2 hr. Seven biochemical blood parameters, including glutathione, red blood cell glutathione reductase, 2,3-diphosphoglycerate, methemoglobin, vitamine E, complement C3, and IgA were measured prior to exposure, immediately after exposure, and 22 hr following exposure. The only variable that showed significant change due to NO2 exposure was glutathione. Glutathione is known to protect the erythrocyte from oxidative stress. The increase in glutathione observed upon exposure to NO2 may be a protective reaction of the erythrocyte to meet the oxidative stress.