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RECORD NUMBER: 5 OF 17

OLS Field Name OLS Field Data
Main Title Effects of 0.1 ppm Nitrogen Dioxide on Airways of Normal and Asthmatic Subjects.
Author Hazucha, Milan J. ; Ginsberg, Joel F. ; McDonnell, William F. ; Haak, Jr., Edward D. ; Pimmel, Russell L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ., Chapel Hill.
Year Published 1983
Report Number EPA-600/J-82-021;
Stock Number PB83-223701
Additional Subjects Nitrogen dioxide ; Toxicology ; Respiratory system ; Asthma ; Exposure ; Physiological effects ; Reprints ; Air pollution effects(Humans)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB83-223701 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 12p
Abstract
It has been reported that inhalation of nitrogen dioxide (NO2) will enhance the bronchial reactivity of asthmatics. This study was designed to evaluate the respiratory effect of a 1-h exposure of normal subjects and of atopic asthmatics to 0.1 parts per million (ppm) NO2. Fifteen normal and 15 asthmatic subjects were exposed to air and to NO2 in randomized double-blind crossover design. Exposure to either atmosphere was bracketed by bronchial inhalation challenge using aerosolized metacholine chloride solutions. Plethysmographic measurements of specific airway resistance (sRaw) and the forced random noise impedance spectrum (5-30 Hz) were obtained immediately after each methacholine dose.