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RECORD NUMBER: 21 OF 53

OLS Field Name OLS Field Data
Main Title Importance of Experimenter-Blind Procedure in Neurotoxicology (Mini-Review).
Author Benignus, V. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/093;
Stock Number PB93-175628
Additional Subjects Toxicology ; Experimental data ; Air pollution effects(Humans) ; Double-blind method ; Statistical analysis ; Neurotoxins ; Carbon monoxide ; Exposure ; Tables(Data) ; Reprints ; Single-blind method ; Meta-analysis
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-175628 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/23/1993
Collation 7p
Abstract
The importance of having the investigator blind to the experimental condition of a human subject was demonstrated using meta analysis of 43 reports of the effects of carbon monoxide (CO) on behavior. It was shown that 75% of single-blind studies found significant CO effects as opposed to only 26% of double-blind studies (difference was significant, p < 0.005). It was also not possible to show that the difference could have been due to different CO exposure levels, different statistical practices, or different study group sizes. The failure to follow double-blind procedure has been partly responsible for disagreement about the effects of CO reported in the literature. Investigator blinding is also important in laboratory animal research. (Copyright (c) 1993 Pergamon Press Ltd.).