Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Failure to Produce Arsenic Neurotoxicity in the Rat. An Experimental Study.
Author Schaumburg, Herbert H. ;
CORP Author American Public Health Association, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1980
Report Number EPA-560/11-80-022;
Stock Number PB80-209505
Additional Subjects Toxicology ; Arsenic ; Rats ; Exposure ; Humans ; Parenteral infusions ; Laboratory animals ; Concentration(Composition) ; Nervous systems ; Toxic substances ; Histopathology ; Neurotoxins ; Animal models
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB80-209505 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 17p
Prolonged, low-level exposure to inorganic arsenic can produce peripheral neuropathy in humans, and is a serious industrial health hazard. The clinical expression of arsenic neuropathy is similar to other toxic neuropathies of the dying-back type. No satisfactory animal model of arsenic neuropathy has been devised. Rats underwent weekly intraperitoneal injections with solutions of arsenic trioxide. Strengths of 2mg/kg, 5mg/kg, 10mg/kg and 15mg/kg were used. The 15 mg/kg animals died shortly after receiving the injection. The other animals survived and, after eighteen months, appeared normal. Histopathological study of the peripheral and central nervous systems of these animals was unremarkable. It appears that the rat is not the appropriate species for the study of inorganic arsenic neurotoxicity.