Main Title |
Synaptic Plasticity and the Mechanism of Alzheimer's Disease [electronic resource] / |
Type |
EBOOK |
Author |
Selkoe, Dennis J.
|
Other Authors |
|
Publisher |
Springer Berlin Heidelberg, |
Year Published |
2008 |
Call Number |
RC321-580 |
ISBN |
9783540763307 |
Subjects |
Medicine ;
Human physiology ;
Neurosciences
|
Internet Access |
|
Collation |
XII, 183 p. online resource. |
Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
Contents Notes |
Permanence of the Synapse and Molecular Instability -- Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity -- Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivo -- Synapse Loss, Synaptic Plasticity and the Postsynaptic Density -- Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity -- Quantitative Neuropathology in Alzheimer's Mouse Models -- Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States -- Soluble Oligomers of the Amyloid ?-Protein: Impair Synaptic Plasticity and Behavior -- Why Alzheimer's is a Disease of Memory: Synaptic Targeting by Pathogenic A? Oligomers (ADDLs) -- Synaptic Transmission Dynamically Modulates Interstitial Fluid Amyloid-? Levels -- A?-Induced Toxicity Mediated by Caspase Cleavage of the Amyloid Precursor Protein (APP) -- Long-Term Potentiation and A?: Targeting A? Species, Cellular Mechanisms and Putative Receptors -- Genes, Synapses and Autism Spectrum Disorders. (will follow) |