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RECORD NUMBER: 5 OF 30

OLS Field Name OLS Field Data
Main Title Biochemical and Morphological Validation of a Rodent Model of OPIDN.
Author Padilla, S. ; Veronesi, B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/D-88/049;
Stock Number PB88-184650
Additional Subjects Rats ; Laboratory animals ; Nervous system disorders ; Phosphorus organic compounds ; Screening ; Morphology ; Tests ; Pathology ; Damage ; Exposure ; Biochemistry ; Enzymes ; Indicator species ; Phosphites ; Esterases ; Phosphorus organic compounds ; Triphenyl phosphite
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB88-184650 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 24p
Abstract
The paper describes six years of research designed to validate the use of the rat as a viable alternative to the hen for screening and mechanistic studies of neuropathic OP compounds. To date the results indicate that if morphological rather than behavioral endpoints are used, the rat may be a more valid indicator of OPIDN. The authors must, however, test the rat with a wider variety of test OPs to substantiate further the NTE/pathology relationship. Over and above the regulatory considerations, the rat, can be successfully used to address, the mechanistic questions of OPIDN and will hopefully be used to unravel those events occurring between OP exposure and the onset of pathological damage.