Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Evaluation of Sensory System Function Using Reflex Modification of the Startle Response.
Author Crofton, K. M. ; Sheets., L. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/445;
Stock Number PB91-109371
Additional Subjects Public health ; Chemical compounds ; Environmental surveys ; Senses ; Exposure ; Toxicology ; Reflexes ; Nervous system disorders ; Reprints ; Toxic substances ; Startle raction
Library Call Number Additional Info Location Last
NTIS  PB91-109371 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 15p
Methods to measure damage to sensory systems following toxicant exposure vary from rapid and subjective tests (e.g., pinna reflex) to time-consuming and objective tests (e.g., psychophysical tests). Reflex modification of the startle response represents an alternative technique in the assessment of sensory function. Advantages of this procedure include: no prior training requirements, rapid and objective measurement of sensory thresholds, ability to differentiate sensory from non-sensory damage, and potential for predictive validity. This procedure has also been shown to be sensitive to a variety of neurotoxic compounds. Future research should concentrate on demonstrating the research potential of this technique for use in neurotoxicology.