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OLS Field Name OLS Field Data
Main Title Acute Sulfolane Exposure Produces Temperature-Independent and Dependent Changes in Visual Evoked Potentials.
Author Dyer, R. S. ; Boyes, W. K. ; Hetzler, B. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/337;
Stock Number PB87-180006
Additional Subjects Nervous system disorders ; Visual perception ; Toxicity ; Exposure ; Organic solvents ; Toxicology ; Convulsive disorders ; Behavior disorders ; Hypothermia ; Rats ; Reprints ; Sulfolane ; Tetrahydrothiophene-1 ; 1-dioxide ; FEP(Flash Evoked Potentials) ; PREPS(Pattern Reversal Evoked Potentials)
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB87-180006 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 9p
Abstract
The report describes the consequences of acute exposure to sulfolane upon the visual system, as measured using flash evoked potential (FEPs) and pattern reversal evoked potentials (PREPs). A single injection of either 1/2 or 1/4, but not 1/8 the i.p. LD50 (1600 mg/kg) produced significant increases in peak latencies of both FEPs and PREPs. These effects of sulfolane were apparent within 1 hour and lasted longer than 6 hours. In addition, sulfolane produced an ambient temperature- and dose-dependent hypothermia. Attenuating hypothermia eliminated the effects of sulfolane on latencies. Amplitudes of FEP peaks to the first of a pair of stimuli were generally increased compared to control, and this effect was probably not temperature dependent. Sulfolane, therefore, produces effects on the visual system, some of which are temperature dependent.