Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title In vitro Screening Batteries for Neurotoxicants.
Author Veronesi., B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA/600/D-91/206;
Stock Number PB91-231233
Additional Subjects Toxic substances ; Toxicity ; Nervous system ; In vitro analysis ; Cell survival ; Tissue culture ; Nerve cells ; Cell line ; Cultured tumor cells ; Tests ;
Library Call Number Additional Info Location Last
NTIS  PB91-231233 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/26/1991
Collation 27p
The need to develop, validate and utilize in vitro models to test chemicals for neurotoxic potential is widely appreciated. The lecture discusses the major advantages and disadvantages of using cell and tissue culture, the various in vitro models amenable for neurotoxicity studies, and the distinction between mechanistic and screening models. Major considerations for designing screening battery to evaluate neurotoxicants are discussed. Topics such as choice of appropriate cell models in the battery, choice and quantification of endpoints (i.e., cytotoxic and neurotoxic), and technical considerations in the design of the battery are discussed.