Record Display for the EPA National Library Catalog

RECORD NUMBER: 296 OF 1145

OLS Field Name OLS Field Data
Main Title Comparison of the Lung Adenoma Response in Strain A/J Mice after Intraperitoneal and Oral Administration of Carcinogens.
Author Stoner, G. D. ; Greisiger, E. A. ; Schut, H. A. J. ; Pereira, M. A. ; Loeb, T. R. ;
CORP Author Medical Coll. of Ohio at Toledo.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA/600/J-84/090;
Stock Number PB84-245521
Additional Subjects Toxicology ; Adenoma ; Bioassay ; Neoplasms ; Mice ; Laboratory animals ; Responses ; Reprints ; Carcinogens
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-245521 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 14p
Abstract
This study was undertaken to compare the ability of a series of compounds from different chemical classes to induce lung tumors in strain A/J mice after either ip or po administration. 3-Methylcholanthrene, benzo(a)pyrene, urethan, diethylnitrosamine, ethylnitrosourea, and dimethylhydrazine induced a significant(p<0.05; t test)increase in the lung tumor response when given both ip and po. 2,4-Dinitrotoluene, 2,6-dinitrotoluene, and a 2:1 mixture of 2,4-dinitrotoluene and 2,6-dinitrotoluene were inactive by both routes of administration and at all dose levels. The lung tumor response to all doses of 3-methylcholanthrene and benzo(a)pyrene, the highest dose of diethylnitrosamine, and the middle doses of both ethylnitrosourea and dimethylhydrazine varied as a function of the route of administration.