Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Comparison of Rat Liver Foci Assay and Strain a Mouse Lung Tumor Assay to Detect Carcinogens: A Review.
Author Pereira, M. A. ; Stoner, G. D. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo.
Year Published 1985
Report Number EPA/600/J-85/222;
Stock Number PB86-118650
Additional Subjects Toxicology ; Malignant neoplasms ; Bioassays ; Rats ; Liver ; Mice ; Comparison ; Reprints ; Carcinogenesis ; Cancer
Library Call Number Additional Info Location Last
NTIS  PB86-118650 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 13p
A comparison was performed of the results reported in the literature of chemicals tested in the rat liver foci assay and/or in the strain A lung tumor assay to the results of the chemicals in long-term carcinogenicity bioassays. The rat liver foci assay was sensitive to 69% of 54 compounds found to be carcinogenic in long-term bioassays and the strain A lung tumor assay to 54% of 93 carcinogens. None of the ten compounds found to be noncarcinogenic in long-term bioassays were active in the rat liver foci assay, while seven of 23 non-carcinogens (30%) were active in the lung tumor assay. Ten of the 16 carcinogens negative in the rat liver foci assay are believed to be tumor promoters; 3 are direct-acting alkylating agents (dimethylsulfate, epichlorohydrin, and beta-propiolactone); and the remaining 4 are azobenzene, 1,2-dibromoethane, oxazepam and thioacetamide.