Record Display for the EPA National Library Catalog

RECORD NUMBER: 264 OF 1145

OLS Field Name OLS Field Data
Main Title Chemical Induction of Tumors in Oysters by a Mixture of Aromatic and Chlorinated Hydrocarbons, Amines and Metals.
Author Gardner, G. R. ; Pruell, R. J. ; Malcolm, A. R. ;
CORP Author Environmental Research Lab., Narragansett, RI.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-93/310 ;ERLN-1281;
Stock Number PB93-229326
Additional Subjects Oysters ; Neoplasms ; Water pollution effects(Animals) ; Chemical water pollutants ; Carcinogens ; Chlorinated hydrocarbons ; Aromatic hydrocarbons ; Amines ; Metals ; Gastrointestinal neoplasms ; Kidney neoplasms ; Sediments ; Prevalence ; Reprints ; Crassostrea virginica
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB93-229326 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 7p
Abstract
Tumors were induced in eastern oysters (Crassostrea virginica) by a mixture of aromatic hydrocarbons, an aromatic amine, polychlorinated biphenyls, chlorinated hydrocarbons, a nitrosoamine and heavy metals. Kidney and enteric tumors developed in oysters following exposure to a mixture containing 3,4-benzopyrene, 1,2-benzanthracene, 2-aminofluorene, N-nitrosodiethylamine, technical chlordane, Aroclors 1242 and 1254, p,p'-DDE, cadmium (CdCl2), chromium (K2CrO4) and lead (Pb(NO3)2). 2-Aminofluorene and N-nitrosodiethylamine, not measured in Black Rock Harbor sediment, were both added at 0.6 and 6.0 micrograms/g dry sediment. A 3% prevalence of low-grade renal and gastrointestinal tumors developed after 30 days in oysters fed water-column suspended sediment particulate spiked with the mixture of chemicals. Disease progression was most advanced in enteric adenomas. Both types are comparable to those produced after 30 days in the same organs by chemically contaminated Black Rock Harbor sediment.