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RECORD NUMBER: 258 OF 1145

OLS Field Name OLS Field Data
Main Title Chemical and Radiation Leukemogenesis in Humans and Rodents and the Value of Rodent Models for Assessing Risks of Lymphohematopoietic Cancers.
Author Eastmond, D. A. ;
CORP Author Calilfornia Univ., Riverside. Environmental Toxicology Graduate Program.;Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Publisher May 97
Year Published 1997
Report Number NCEA-W-0275 ; EPA/600/R-97/090
Stock Number PB97-208185
Additional Subjects Leukemogenesis ; Chemical warfare agents ; Ionizing radiation ; Genetic effects ; Bioassay ; Animal models ; Mice ; Rats ; Toxic substances ; Alkylating agents ; Podophyllotoxin ; Benzene ; Butadienes ; Exposure ; Chromosomal aberrations ; Genetic radiation effects ; Hematopoiesis ; Leukopoiesis ; Lymphotcytes ; Leukemia ; Neoplasms ; Inhibitors ; Humans ; Dioxopiperazine
Holdings
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Status
NTIS  PB97-208185 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/22/1997
Collation 131p
Abstract
This report is intended to provide an up-to-date overview of the lymphoid and hematopietic diseases induced in humans and rodents following exposure to chemical agents. It includes a brief introduction to hematopoiesis and lymphopoiesis in humans and rodents, selected characteristics of known leukemia-inducing agents and their effects in mice and rats are compared and the value of rodents models. Six different classes of established leukemia-inducing agents were included: in ionizing radiation, alkylatingagents, epipodophyllotoxin-type topoisomerase inhibitors, dioxopiperazine-type topoisomerase inhibitors, benzene, and 1,3 butadiene. The current understanding of mechanisms underlying acute nonlymphocytic leukemia in humans and thymic lymphoma and myeloid leukemia in mice is presented. The relevance of mouse models for human leukemias and lymphomas is discussed. Furthermore, chronic animal bioassays using mouse models have been shown to be effective in identifying human leukemia-inducing agents.