Record Display for the EPA National Library Catalog
RECORD NUMBER: 435 OF 1142Main Title | Evaluation of the potential carcinogenicity of 2-nitropropane (79-46-9) / | |||||||||||
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CORP Author | Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
Publisher | U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; | |||||||||||
Year Published | 1988 | |||||||||||
Report Number | EPA-68-03-3112; EPA-68-03-3182; EPA/600/8-91/157; OHEA-C-073-145 | |||||||||||
Stock Number | PB93-196418 | |||||||||||
Subjects | 2-Nitropropane--Carcinogenicity | |||||||||||
Additional Subjects | Toxicity ; Risk assessment ; Public health ; Exposure ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; Propane/2-nitro ; Carcinogenicity ; Dose-response relationships ; CAS: 79-46-9 | |||||||||||
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Collation | 16 pages ; 28 cm | |||||||||||
Abstract | 2-Nitropropane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Inadequate'. The results of the two available inhalation bioassays for 2-nitropropane offer a wide range of potency factor (F) values using the conventional RQ methodology, yet the shortcomings of the bioassays are significant. A specific potency for 2-nitropropane is not adopted in the analysis and by default 2-nitropropane is assigned to potency group 2. Combining the weight-of-evidence group and the potency group, 2-nitropropane is assigned a 'MEDIUM' hazard ranking. |
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Notes | Cover title. "June 1988." Includes bibliographical references. Microfiche. |