Includes bibliographical references and index.

Principles of harm reduction -- Historical perspective and lessons learned -- Products for tobacco exposure reduction -- The scientific basis for prep assessment -- Surveillance for the health and behavioral consequences of exposure reduction -- Implementation of a science-based policy of harm reduction -- Principle conclusions -- Evidence for the science base -- Nicotine pharmacology -- Tobacco smoke and toxicology -- Exposure and biomarker assessment in humans -- Cancer -- Cardiovascular disease -- Nonneoplastic respiratory diseases -- Reproductive and developmental effects -- Other health effects -- Appendices -- Presentations and submissions -- Committee biographical sketches -- Time line of tobacco events.