||Method for the Determination of 1-Naphthol in Urine.
Shafik, M. T. ;
Sullivan, H. C. ;
Enos., H. F. ;
||Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Chemical analysis ;
Naphthalene compounds ;
Experimental data ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Humans exposed industrially to the insecticide carbaryl (1-naphthyl N-methylcarbamate) excrete relatively large quantities of 1-naphthol conjugated either as the sulfate or glucuronide. A colorimetric procedure is generally used to quantitatively determine 1-naphthol in human urine. However, this method lacks both the sensitivity and specificity necessary for determining the relatively small amounts of 1-naphthol excreted in the urine of agricultural workers exposed to low levels of carbaryl. The object of this investigation was to develop a rapid, sensitive method for the determination of 1-naphthol in human urine.