Record Display for the EPA National Library Catalog

RECORD NUMBER: 12 OF 16

OLS Field Name OLS Field Data
Main Title Metabolism of 2-Methylnaphthalene to Isomeric Dihydrodiols by Hepatic Microsomes of Rat and Rainbow Trout.
Author Breger, R. K. ; Franklin, R. B. ; Lech, J. J. ;
CORP Author Medical Coll. of Wisconsin, Inc., Milwaukee.;Environmental Research Lab.-Duluth, MN.
Year Published 1981
Report Number EPA-R-806878; EPA-600/J-81-649;
Stock Number PB84-101310
Additional Subjects Ribosomes ; Naphthalene compounds ; Rats ; Fishes ; In vitro analysis ; In vitro analysis ; Reprints ; Rainbow trout ; Naphthalene/methyl ; Dihydrodiols
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-101310 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
Abstract
The metabolism of 2-methylnaphthalene in rats (in vivo and in vitro) and rainbow trout (in vitro) has been investigated. Three isomeric dihydrodiols were formed by microsomal preparations and these were isolated and identified by high-pressure liquid chromatography and gas chromatography/mass spectroscopy. The temperature, microsomal protein content, and incubation time were varied to obtain the optimum conditions for their formation. The conversion of 2-methylnaphthalene to both monohydroxylated compounds and dihydrodiols was reduced by incubation with carbon monoxide, the omission of NADPH, or use of heat-denatured microsomes, implying the involvement of cytochrome(s) P-450-linked mixed-function oxidase activity.