Record Display for the EPA National Library Catalog

RECORD NUMBER: 35 OF 287

OLS Field Name OLS Field Data
Main Title Cho/hgprt Mammalian Cell Foward Gene Mutation Assay with Acetone Cyanohydrin with Cover Letter dated 04/25/1986.
CORP Author Pharmakon Research International, Inc., Waverly, PA.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 878216402
Stock Number OTS0510330
Additional Subjects Toxicology ; Health effects ; Acetone Cyanohydrin (75-86-5) ; Genotoxicity ; Gene Mutations ; Mammals ; Hamsters ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 75-86-5
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Status
NTIS  OTS0510330 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 123p
Abstract
The ability of acetone cyanohydrin to induce mutations at the HGPRT gene locus in Chinese Hamster Ovary (CHO) cells in vitro was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Based on preliminary toxicity determinations, acetone cyanohydrin was tested for mutagenicity at 5 concentrations over the range of 100-950 ug/ml, with cell survival ranging from 101-37% without activation and 102-49% with activation. There were no significant differences between treated and control (untreated) cultures with respect to mutation frequencies at any of the concentrations tested, either with or withoutactivation.