Record Display for the EPA National Library Catalog

RECORD NUMBER: 21 OF 287

OLS Field Name OLS Field Data
Main Title Benz(j)aceanthrylene: A Novel Polycyclic Aromatic Hydrocarbon with Bacterial Mutagenic Activity.
Author Sangaiah, R. ; Gold, A. ; Toney, G. E. ; Toney, S. H. ; Claxton, L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/J-83-013;
Stock Number PB83-213918
Additional Subjects Mutagens ; Salmonella ; Environmental surveys ; Mutations ; Aromatic hydrocarbons ; Bacteria ; Metabolism ; Toxicology ; Reprints ; Benzaceanthrylene ; Mutagenesis ; Dihydroglycol
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB83-213918 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract
Initial studies on the mutagenicity and metabolism of a novel cyclopenta-PAH, benz(j) aceanthrylene, are reported in the Salmonella bacterial system. The spectrum of activity of benz(j)aceanthrylene over the 5 Ames tester strains is similar to that of benzo(a)pyrene, and the dose-response curves for strain TA98 are comparable. Like other biologically active PAH, benz(j)aceanthrylene is a frame-shift mutagen requiring metabolic activation. An interesting feature of the S9 dependence of activity is the low concentration (about 10-fold smaller than for benzo(a)pyrene) at which optimal activity is observed. The 1,2-dihydro-1,2-diol (product of metabolism of the cyclopenta-ring) appears to be the predominant metabolite, and implicates the 1,2-oxide as the ultimate mutagenic species.