Record Display for the EPA National Library Catalog
RECORD NUMBER: 19 OF 287
|OLS Field Name||OLS Field Data|
|Main Title||Bacterial Reverse Mutation Assay using Vapor-Phase Exposure for 1,6-Hexamethylene Diisocyanate, with Cover Letter dated 09/20/1998.|
|CORP Author||Microbiological Associates, Bethesda, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; 1 ; 6-hexamethylene diisocyante ; Genotoxicity ; Gene mutations ; Bacteria ; In vitro ; CAS No 822-06-0|
The test substance, 1,6 - hexamethylene diisocyanate, was tested in the bacterial reverse mutation assay using S. typhimwium tester strains TA98, TA100, TA1535 and TA1537 in the presence and absence of Aroclor-induced rat liver S9. The assay was performed in two phases, using the vapor-phase exposure method. The first phase, the preliminary toxicity assay, was used to establish the dose range for the mutagenicity assay. The second phase, the mutagenicity assay, was used to evaluate the mutagenic potential of the test substance.