Record Display for the EPA National Library Catalog
RECORD NUMBER: 188 OF 286
|OLS Field Name||OLS Field Data|
|Main Title||Mutagenic Activity of Carbitol in the Salmonella/microsome Assay with Attachments and Cover Sheet Dated 06/12/1989 (Sanitized).|
|CORP Author||Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Diethylene Glycol Monoethyl Ether (111-90-0) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 111-90-0|
The mutagenicity of Carbitol (diethylene glycol monoethyl ether) was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537, and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, the material was tested for mutagenicity at concentrations of 0, 3000, 6000, 9000, 12000, 15000, and 20000 ug/plate using the direct plate incorporation method. Carbitol did not cause a reproducible positive response in any of the bacterial tester strains, either in the presence or absence of added metabolic activation.