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RECORD NUMBER: 187 OF 287

OLS Field Name OLS Field Data
Main Title Mutagenic Activity in the Salmonella/microsome Assay with Attachments, Cover Sheets and Letter Dated 09/24/1984 (Sanitized).
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-890000815S
Stock Number OTS0520932
Additional Subjects Toxicology ; Health effects ; Methyl Methacrylate (80-62-6) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 80-62-6
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NTIS  OTS0520932 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 17p
Abstract
The mutagenicity of methacrylic acid, methyl ester was evaluated in Salmonella tester strains TA98, TA100, TA1535, and TA1537 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, the material was tested for mutagenicity at doses of 0, 1000, 2500, 5000, 7500, and 10000 ug/plate using the direct plate incorporation method; mutagenicity was additionally tested for in strain TA100 at concentrations of 0, 10, 25, and 50 mM using the suspension assay. The material was found to be mutagenic in strain TA100, in the presence of activation, in the suspension assay. Methacrylic acid, methyl ester did not cause a reproducible positive response in tester strains TA98, TA100, TA1535, or TA1537, either in the presence or absence of added metabolic activation, in the direct plate incorporation assay.