Record Display for the EPA National Library Catalog
RECORD NUMBER: 185 OF 287Main Title | Mutagenesis and Morphological Transformation of Mammalian Cells by a Non-Bay-Region Polycyclic Cyclopenta(cd)pyrene and Its 3,4-Oxide1. | |||||||||||
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Author | Gold, Avram ; Nesnow, Stephen ; Moore, Martha ; Garland, Helen ; Curtis, Gaynelle ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Year Published | 1980 | |||||||||||
Report Number | EPA-600/J-80-304; | |||||||||||
Stock Number | PB81-222234 | |||||||||||
Additional Subjects | Toxicology ; Cells(Biology) ; Morphology ; Mammals ; Cultures(Biology) ; Mutations ; Nitrogen organic compounds ; Reprints ; Cyclopentapyrene ; Mutagenesis ; Toxic substances ; Cell cultures ; Metabolites ; Cyclopentapyrene oxide | |||||||||||
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Collation | 5p | |||||||||||
Abstract | Cyclopenta(cd)Pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to a be direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon. |