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RECORD NUMBER: 157 OF 287

OLS Field Name OLS Field Data
Main Title Letter from American Petroleum Institute to US EPA regarding Submission of 8(e) Information on Three Commercial Solvents with Attachments.
CORP Author American Petroleum Inst., Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1977
Report Number 8EHQ-1077-0010
Stock Number OTS0200393
Additional Subjects Toxicology ; Health effects ; Petroleum hydrocarbons ; Genotoxicity ; Chromosomal effects ; Mammals ; Rats ; Parenteral ; Mice ; Subcutaneous ; Gene mutations ; Bacteria ; CAS No 1130-20-7 ; CAS No 8052-41-3 ; CAS No 64741-46-4 ; CAS No 64741-66-8 ; CAS No 64741-84-0 ; CAS No 64741-98-6 ; CAS No 64741-99-7 ; CAS No 64742-81-0 ; CAS No 64742-88-7 ; CAS No 64742-89-8 ; CAS No 64742-94-5 ; CAS No 64742-95-6 ; CAS No 64742-96-7
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Library Call Number Additional Info Location Last
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NTIS  OTS0200393 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 04/28/2010
Collation 880p
Abstract
Mutagenicity studies were conducted on 3 petroleum fractions: rubber solvent, (identified as either a single chemical or a mixture of CAS 64742-89-8 and 64741-84-0); 60 solvent,(a blend of any or all of the following: CAS 64741-46-4, 64741-66-8, 64741-99-7, 64741-84-0, 64742-88-7, 64742-95-6), and high aromatic solvent, (either a single chemical or mixture of CAS 64742-95-6, 64742-94-5, 64741-99-7, 64741-98-6). Cytogenetic assays were conducted with male Long-Evans rats (30/group) administered 1.5 ml/kg of a negative control of 1.5 ml/kg water, or 20 mg/kg of the positive control, 7,12- dimethylbenz(a)anthracene by intraperitonal injection. Increased Type I and Type II chromosomal aberrations were observed in both and within 1 day, and showed increased Type I aberrations within 7 days post-treatment. Three-tier testing of (I) and (II) showed the following: no evidence of mutagenicity in microsome plate assays with 5 tester strains of Salmonella typhimurium and Saccharomyces cerevisiae strain D4, with and without S9; no evidence of forward mutations in the L5178Y mouse lymphoma assay; no evidence of chromosomal aberrations in the cytogenetic analysis of bone marrow cells from exposed male Sprague-Dawley rats; and no evidence of compound-induced lethality in the dominant lethal assay with rats. Ten additional petroleum fractions tested for dominant lethality to mice showed no evidence of mutagenic potential.