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RECORD NUMBER: 151 OF 287

OLS Field Name OLS Field Data
Main Title Kronitex Tbp (tributyl Phosphate) Mutagenicity Screening Test Salmonella Microsomal Assay (ames Test) with Cover Letter dated 08/08/1986.
CORP Author FMC Corp., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 86860000112
Stock Number OTS0510260
Additional Subjects Toxicology ; Health effects ; Phosphoric Acid Tributyl Ester (126-73-8) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 126-73-8
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NTIS  OTS0510260 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 25p
Abstract
The mutagenicity of tri-n-butyl phosphate was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537 and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Tri-n-butyl phosphate, diluted with DMSO, was tested at concentrations up to 100ul/plate using the plate incorporation technique. Tri-n-butyl phosphate did not produce a positive response in any tester strain with metabolic activation. Tester strains TA1535, TA1537 and TA1538 without metabolic activation, produced twice the number of revertants/plate compared to the solvent control (DMSO) for at least three of the five test concentrations, but a dose-response was not observed.