Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Kronitex Tbp (tributyl Phosphate) Mutagenicity Screening Test Salmonella Microsomal Assay (ames Test) with Cover Letter dated 08/08/1986.
CORP Author FMC Corp., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 86860000112
Stock Number OTS0510260
Additional Subjects Toxicology ; Health effects ; Phosphoric Acid Tributyl Ester (126-73-8) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 126-73-8
Library Call Number Additional Info Location Last
NTIS  OTS0510260 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 25p
The mutagenicity of tri-n-butyl phosphate was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537 and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Tri-n-butyl phosphate, diluted with DMSO, was tested at concentrations up to 100ul/plate using the plate incorporation technique. Tri-n-butyl phosphate did not produce a positive response in any tester strain with metabolic activation. Tester strains TA1535, TA1537 and TA1538 without metabolic activation, produced twice the number of revertants/plate compared to the solvent control (DMSO) for at least three of the five test concentrations, but a dose-response was not observed.