Record Display for the EPA National Library Catalog
RECORD NUMBER: 31 OF 241
|OLS Field Name||OLS Field Data|
|Main Title||Biochemical, Functional and Morphological Indicators of Neurotoxicity: Effects of Acute Administration of Trimethyltin to the Developing Rat.|
|Author||Miller, D. B. ; O'Callaghan, J. P. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Organometallic compounds ; Toxicity ; Morphology ; Bioassay ; Rats ; Brain ; Hippocampus ; Behavior ; Learning ; Trimethyltin compounds ; Neutrotoxins ; Dose rate|
The neurotoxic organometal, trimethyltin (TMT), was administered to rats on postnatal day (PND)5. Neurotoxicity was assessed throughout subsequent development using morphological, biochemical and functional endpoints. These consisted of brain weight measures and histology (morphology), assays of nervous system-specific proteins (biochemistry) and neurobehavioral indices of activity and learning (function). All three indices were affected.