||Computer Automated Structure Evaluation (CASE) of Flavonoids as Larval Growth Inhibitors.
Klopman, G. ;
Venegas, R. E. ;
||Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA.
Growth regulators ;
Molecular structure ;
Computer automated structure evaluation(CASE) ;
Heliothis zea ;
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The Computer Automated Evaluation program(CASE) has been used to analyze the inhibition of the larval growth in the H. Zea system by flavonoid derivatives. A quantitative structure-activity relationship was established between molecular fragments generated by the CASE methodology and the activity of the flavonoids. A good correlation with experimental values is obtained. (Copyright (c) 1988 IUPAC.)