Record Display for the EPA National Library Catalog
RECORD NUMBER: 145 OF 265
|OLS Field Name||OLS Field Data|
|Main Title||Reanalysis and Clarification of the Structures of alpha-Naphthoflavone Dihydrodiols Formed by Uninduced and Induced Rat Liver Microsomes from Charles River CD and Sprague-Dawley Rats.|
|Author||Nesnow, S. ; Bryant, B. J. ; Rudo, K. ; Easterling, R. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toxicology ; Liver neoplasms ; Metabolism ; Environmental surveys ; Molecular structure ; Laboratory animals ; Rats ; Ribosomes ; Comparison ; Water pollution ; Reprints ; Naphthopyranone/phenyl ; Benzoflavone ; Water pollution effects(Animals) ; Cancer ; Naphthopyranone dihydrodiol/phenyl|
The structures of alpha-naphthoflavone (ANF) dihydrodiols formed by uninduced and induced rat liver microsomes are identified by conversion of the metabolically formed ANF-dihydrodiols to the corresponding phenols. Comparison of these phenols with synthetic standards provides an unambiguous method for structural identification. The results of these studies are that hepatic microsomes from uninduced or phenobarbital, Aroclor-1254, 3-methylcholanthrene, or 5,6-benzoflavone induced Sprague-Dawley or Charles River CD rats each produce a major and a minor ANF-dihydrodiol identified as ANF-7,8-dihydrodiol and ANF-5,6-dihydrodiol, respectively.