Record Display for the EPA National Library Catalog

RECORD NUMBER: 145 OF 265

OLS Field Name OLS Field Data
Main Title Reanalysis and Clarification of the Structures of alpha-Naphthoflavone Dihydrodiols Formed by Uninduced and Induced Rat Liver Microsomes from Charles River CD and Sprague-Dawley Rats.
Author Nesnow, S. ; Bryant, B. J. ; Rudo, K. ; Easterling, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/J-83-218;
Stock Number PB84-206127
Additional Subjects Toxicology ; Liver neoplasms ; Metabolism ; Environmental surveys ; Molecular structure ; Laboratory animals ; Rats ; Ribosomes ; Comparison ; Water pollution ; Reprints ; Naphthopyranone/phenyl ; Benzoflavone ; Water pollution effects(Animals) ; Cancer ; Naphthopyranone dihydrodiol/phenyl
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB84-206127 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract
The structures of alpha-naphthoflavone (ANF) dihydrodiols formed by uninduced and induced rat liver microsomes are identified by conversion of the metabolically formed ANF-dihydrodiols to the corresponding phenols. Comparison of these phenols with synthetic standards provides an unambiguous method for structural identification. The results of these studies are that hepatic microsomes from uninduced or phenobarbital, Aroclor-1254, 3-methylcholanthrene, or 5,6-benzoflavone induced Sprague-Dawley or Charles River CD rats each produce a major and a minor ANF-dihydrodiol identified as ANF-7,8-dihydrodiol and ANF-5,6-dihydrodiol, respectively.