Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Predicting Modes of Toxic Action from Chemical Structure: An Overview.
Author Bradbury, S. P. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Publisher 1994
Year Published 1994
Report Number EPA/600/J-94/258;
Stock Number PB94-176195
Additional Subjects Toxicity ; Fishes ; Water pollution effects(Animals) ; Aquatic animals ; Dose-response relationships ; Marine biology ; Hazardous materials ; Exposure ; Chemical properties ; Biological effects ; Predictions ; Molecular structure ; Mutagens ; Carcinogens ; Reprints ; QSAR(Quantitative structure activity relationships)
Library Call Number Additional Info Location Last
NTIS  PB94-176195 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/01/1994
Collation 18p
In the field of environmental toxicology, and especially aquatic toxicology, quantitative structure activity relationships (QSARs) have developed as scientifically-credible tools for predicting the toxicity of chemicals when little or not empirical data are available. A basic and fundamental understanding of toxicological principles has been considered crucial to the continued acceptance and application of these techniques as biologically relevant. As a consequence, there has been an evolution of QSAR development and application from that of a chemical-class perspective to one that is more consistent with assumptions regarding modes of toxic action. The assessment of a compound's likely mode of toxic action is critical for a correct QSAR selection; incorrect mode of action-based QSAR selections can result in 10- to 1000-fold errors in toxicity/predictions. (Copyright (c) 1994 Gordon and Breach Science Publishers S.A.)