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RECORD NUMBER: 118 OF 265

OLS Field Name OLS Field Data
Main Title Polychlorinated Biphenyls as Inducers of Hepatic Microsomal Enzymes: Structure-Activity Rules.
Author Parkinson, A. ; Robertson, L. ; Safe, Lorna ; Safe, S. ;
CORP Author Guelph Univ. (Ontario).;Environmental Research Lab.-Duluth, MN.
Year Published 1980
Report Number EPA-R-806928; EPA-600/J-80-419;
Stock Number PB83-243741
Additional Subjects Enzymes ; Ribosomes ; Molecular structure ; Laboratory animals ; In vivo analysis ; Bioassay ; Toxicity ; Public health ; Chlorine organic compounds ; Rats ; Dosage ; Liver ; Reprints ; Polychlorinated biphenyls ; Toxic substances ; Chemical shifts(Nuclear magnetic resonance)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB83-243741 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 18p
Abstract
A number of highly purified polychlorinated biphenyl (PCB) isomers and congeners were synthesized and administered to male Wistar rats at dosage levels of 30 and 150 micromol/kg. The effects of this in vivo treatment on the drug-metabolizing enzymes were determined by measuring the microsomal benzo(a)pyrene (B(a)P) hydroxylase, dimethylaminoantipyrine (DMAP) N-demethylase and NADPH-cytochrome c reductase enzyme activities, the cytochrome b sub 5 content and the relative peak intensities of spectral shifts of the reduced microsomal cytochrome P-450:CO and ethylisocyanide (EIC) binding difference spectra.