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RECORD NUMBER: 6 OF 265

OLS Field Name OLS Field Data
Main Title Analysis of the Spectra of Genetic Activity in Short-Term Tests.
Author Waters, M. D. ; Stack, H. F. ; Brady, A. L. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-68-02-4031; EPA/600/D-85/205;
Stock Number PB86-102613
Additional Subjects Bioassays ; Genetics ; Carcinogens ; Environmental surveys ; Toxicity ; Spectrochemical analyses ; Molecular structure ; Dosage ; In vitro analysis ; In vivo analysis ; Public health ; Information systems ; Chemical analysis ; Pesticides ; Solvents ; Tables(Data) ; Environmental health ; Genetic activity spectra ; Toxic substances ; Computer applications
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NTIS  PB86-102613 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 15p
Abstract
For agents classified by IARC as known or suspected human carcinogens and for over 100 other chemical pesticides, solvents, intermediates and final products, we have extracted and recorded qualitative and quantitative genetic bioassay data available in the literature. Either the lowest effective dose (LED) or the highest ineffective dose (HID) tested was recorded for each agent and bioassay system. The systems were organized according to classes of genetic activity and subdivided by the phylogenetic level of the test organism. For each compound, the quantitative results in the test systems were represented by computer-generated bar graphs, so-called 'genetic activity spectra.' Statistical methods and pattern recognition techniques were used to evaluate the activity profiles of compounds in a pairwise manner. The results showed that structurally similar compounds frequently displayed qualitatively and quantitatively similar profiles of genetic activity. As the database is enlarged, the analysis of genetic activity profiles may contribute to our understanding of structure-activity relationships and mechanisms of action of chemical agents. Such a method of presentation could well serve as a medium for international exchange and evaluation of genetic bioassay data.