Chondrogenesis, chondrocytes, and cartilage -- Molecular basis of cell-cell interaction and signaling in mesenchymal chondrogenesis / Rocky S. Tuan -- Chondrocyte cell fate determination in response to bone morphogenic protein signaling / Lillian Shum [and others] -- Regulation of chondrocyte differentiation / Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe -- Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice / Shu Takeda [and others] -- Molecular biology and biosynthesis of collagens / Johanna Myllyharju -- Mechanotransduction pathways in cartilage / Qian Chen -- Control of skeletal development. Molecular genetic analysis of the role of the HoxD complex in skeletal development: impact of the IoxP/Cre system in targeted mutagenesis of the mouse HoxD complex / Marie Kmita, Denis Duboule, and Jáuzsef Zakany -- Control of development and homeostasis via regulation of BMP, Wnt, and hedgehog signaling / Renee Hackenmiller, Catherine Degnin, and Jan Christian -- FgF4 and skeletal morphogenesis / Valerie Ngu-Muller [and others] -- Retinoid signaling and skeletal development / Andrea D. Weston and T. Michael Underhill. Retinoids and Indian hedgehog orchestrate long bone development / Maurizio Pacifici, Eleanor Golden, and Eiki Koyama -- Osteoblastic cell differentiation -- Synergy between osteogenic protein-1 and osteotropic factors in the stimulation of rat osteoblastic cell differentiation / John C. Lee and Lee-Chuan Yeh -- Bone morphogenic proteins, osteoblast differentiation, and cell survival during osteogenesis / Cun-Yu Wang -- Osteoclast differentiation / Sakamuri V. Reddy and G. David Roodman -- Bone induction, growth, and remodeling -- Soluble signals and insoluble substrata: novel molecular cues instructing the induction of bone / Ugo Ripamonti [and others] -- Perichondrial and periosteal regulation of endochondral growth / Dana L. Di Nino and Thomas F. Linsenmayer. Computer simulations of cancellous bone remodeling / J.C. van der Linden, Harrie Weinans, and J.A.N. Verhaar -- The effects of microgravity on skeletal remodeling and bone cells / Pierre J. Marie -- Bone mineralization -- Quantitative analyses of the development of different hard tissues / Siegfried Arnold, Hans J. Hèohling, and Ulrich Plate -- Fetal mineral homeostasis and skeletal mineralization / Christopher S. Kovacs -- Control of osteoblast function and bone extracellular matrix and mineralization by vitamin D / Johannes P.T.M. van Leeuwen, M. van Driel and H.A.P. Pols -- Skeletal dysmorphology -- Role of Pax3 and PDGF-a receptor in skeletal morphogenesis and facial clefting / Simon J. Conway -- Genetics of achondroplasia and hypochondroplasia / Giedre Grigelioniene -- Effects of boric acid on hox gene expression and the axial skeleton in the developing rat / Michael G. Narotsky [and others] -- Toxicant-induced lumbar and cervical ribs in rodents / John M. Rogers, R. Woodrow Setzger, and Neil Chernoff. Experimental skeletal dysmorphology: risk assessment issues / Rochelle W. Tyl, Melissa C. Marr, and Christina B. Myers. In this book, established biomedical researchers, developmental biologists, and clinical practitioners offer a cutting-edge survey of diverse critical issues in bone biology. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors focus on the biochemical, genetic, and molecular interactions that support the development and hemeostasis of the skeleton. Their state-of-the-art understanding of bone physiology - and how it is modified throughout all the stages of life - offers novel aproaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity (space flight), and hastening the healing of fractures, osteotomies, and arthrodeses.