The Community Multiscale Air Quality (CMAQ)/Plume-in-Grid (PinG) model was applied on a domain encompassing the greater Nashville, Tennessee region. Model simulations were performed for selected days in July 1995 during the Southern Oxidant Study (SOS) field study program which was conducted in the Nashville area. In particular, five major point sources exhibiting a range of NO-x emission rates were selected for the PinG treatment. Selected PinG model concentrations and representative examples of the initial results of an ongoing evaluation of the PinG model with the SOS/Nashville data are presented to provide a preliminary demonstration of the capability of the CMAQ/PinG approach. In particular, modeled concentrations of ozone, SO2, and nitrogen oxides are compared to plume data collected during horizontal traverses by an instrumented helicopter and research aircraft across different plumes. Statistical results are also provided at 40 km downwind of the largest point source. The comparisons and quantitative results are encouraging as PinG exhibited the capability to realistically simulate the observed photochemical evolution for ozone and other species at various downwind distances for these cases.