Main Title |
CASE (Computer Automated Structure Evaluation) Study of In vitro Inhibition of Spareteine Monooxygenase. |
Author |
Klopman, G. ;
Venegas, R. E. ;
|
CORP Author |
Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA. |
Publisher |
c1986 |
Year Published |
1986 |
Report Number |
EPA-R-812264; EPA/600/J-86/513; |
Stock Number |
PB90-106394 |
Additional Subjects |
Enzyme inhibitors ;
In vitro analysis ;
Tables(Data) ;
Reprints ;
Expert systems ;
Mixed function oxidases ;
Sparteine monooxygenase ;
Computer automated structure evaluation(CASE) ;
Structure-activity relationship
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-106394 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
21p |
Abstract |
The Computer Automated Structure Evaluation program (CASE) has been used to analyze the in vitro inhibition of sparteine monooxygenase. A significant correlation between the Log10 P (1-octanol/water) of the 74 drugs studied and their inhibitory potency is observed. |