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RECORD NUMBER: 3 OF 17

OLS Field Name OLS Field Data
Main Title Benomyl-Induced Craniocerebral Anomalies in Fetuses of Adequately Nourished and Protein-Deprived Rats.
Author Ellis, W. G. ; Semple, J. L. ; Hoogenboom, E. R. ; Zeman, F. J. ; Kavlock, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. School of Medicine.
Year Published 1987
Report Number EPA/600/J-87/346;
Stock Number PB88-215280
Additional Subjects Reproduction(Biology) ; Toxicity ; Rats ; Laboratory animals ; Abnormalities ; Embryos ; Benzimidazoles ; Fungicides ; Proteins ; Diets ; Dosage ; Reprints ; Benomyl ; Environmental health ; Microtubules ; Tubulin ; Brain diseases ; Mitosis ; Cell migration inhibition
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-215280 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 21p
Abstract
Benomyl, a benzimidazole fungicide, produced craniocerebral and systemic malformations in fetal rats when administered by gavage in doses of 31.2, 62.5, and 125 mg/kg of maternal body weight on days 7-21 of gestation. Malformations increased in incidence and severity with increasing benomyl dosage and nearly doubled when coupled with a protein efficent diet. Protein deficiency alone produced only decreased fetal weight. High benomyl doses produced higher percentages of fetal resorptions and late fetal deaths, and these percentages also increased with protein deficiency. The most common combination of anomalies was hydrocephalus, exencephaly, and periventricular 'overgrowth'. Common systemic malformations included cleft palate, micromelia, hydroureter, and mishapen tails. No fetus was entirely normal at the highest benomyl dose. Thus, it is suggested that benomyl, coupled with a protein-deficient diet, offers a teratogenic model with a spectrum of abnormalities similar to hypervitaminosis A but with a higher yield of specific craniocerebral anomalies. (Copyright (c) 1987 Alan R. Liss, Inc.)