||Localization of the Mouse Thymidine Kinase Gene to the Distal Portion of Chromosome 11.
Hozier, J. ;
Scalzi, J. ;
Sawyer, J. ;
Carley, N. ;
Applegate., M. ;
||Florida Inst. of Tech., Melbourne. Dept. of Biological Sciences. ;Applied Genetics Labs., Inc., Melbourne, FL. ;Burroughs Wellcome Co., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Thymidine kinase ;
Deoxyribonucleic acids ;
Chromosome mapping ;
Nucleic acid hybridization ;
Chromosome aberrations ;
Nucleic acid sequence homology ;
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The authors report the cytogenetic mapping of the thymidine kinase (tk-1) gene in the mouse using two complementary and independent analyses: (1) investigation of chromosome aberrations associated with tk-1 gene inactivation in the L5178Y TK(+/-) -3.7.2C cell line, and (2) fluorescence in situ molecular hybridization of cloned tk-1 cDNA probes to mitotic chromosomes of the cell line. The consensus location from both analyses is 11E1-E2. Consideration of the mouse tk-1 gene localization, along with evidence that the homologous human TK1 gene is located distally on the large arm of chromosome 17, appears to extend the region of homology between MMU11 and HSA17 to the distal end of both chromosomes. (Copyright (c) 1991 by Academic Press, Inc.)