Record Display for the EPA National Library Catalog

RECORD NUMBER: 49 OF 66

OLS Field Name OLS Field Data
Main Title Pesticide Effects on Prenatal Cardiovascular Physiology. I. An Electrocardiographic Study of Mirex-Exposed Rat Fetuses and Newborns. II. An Analysis of the Causes of Perinatal Deaths Induced by Prenatal Exposure to Mirex.
Author Grabowski, Casimer T. ;
CORP Author Miami Univ., Coral Gables, FL. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-R-8053010; EPA-600/1-80-032;
Stock Number PB81-104739
Additional Subjects Toxicology ; Pesticides ; Cardiovascular system ; Pregnancy ; Chlorine organic compounds ; Rats ; Physiological effects ; Electrocardiography ; Bioassay ; Ingestion(Biology) ; Toxic substances ; Mirex ; Fetuses
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=P100PXMS.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB81-104739 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 46p
Abstract
Sperm-positive rats were intubated with Mirex in oil (5 to 10 mg/kg) on days 8-1/2 to 15-1/2. Controls were untreated or oil-fed. Testing was done on day 18-1/2. Fetuses were sequentially exposed and ECG's obtained with the fetus attached to the placenta and uterus. Counterparts of standard leads, I, II and II were used. Fetuses were weighed and examined afterwards. Swollen fetuses were rated on a scale of 1 (slight edema under chin) and 5 (3 mm edema across back). ECG's from 81 controls and 205 Mirex fetuses were obtained. They were evaluated for rate of heart beat, regularity of beat, PR intervals and other features. One control exhibited an abnormality, a transitory period of premature atrial contractions. Mirex-fed fetuses exhibited tachycardia, closely correlated with degree of edema. The heart rate increased from 150/min in controls to 180 in slightly swollen to 224 in swollen fetuses. Mean PR intervals increased with degree of swelling and with dose. The frequency of first degree heart block was also dose-related, ranging from 20% to 77%. Second degree heart blocks were found in 8%, 3% showed arrhythmias, and one had atrial flutter/fibrillation. These cardiovascular problems seem primarily related to Mirex-induced edema and demonstrate that fetal edema is not innocuous. These data demonstrate the usefulness of fetal electrocardiography to detect functional teratology.