Record Display for the EPA National Library Catalog

RECORD NUMBER: 94 OF 1237

OLS Field Name OLS Field Data
Main Title Carcinogenic Activity of Haloacetonitriles and Haloacetone Derivatives in the Mouse Skin and Lung.
Author Bull, R. J. ; Robinson, M. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA-600/D-84-185;
Stock Number PB84-215508
Additional Subjects Toxicology ; Water treatment ; Disinfectants ; Hazardous materials ; Potable water ; Chlorination ; Mutagens ; Disinfection ; Assessments ; Substitutes ; Halogen organic compounds ; Mice ; Laboratory animals ; Chemical reactions ; Rats ; Halomethanes ; Acetone/dichloro ; Acetone/trichloro ; Acetonitrile/chloro ; Acetonitrile/dichloro ; Acetonitrile/trichloro ; Acetonitrile/bromo-chloro ; Acetonitrile/dibromo ; Cancer
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-215508 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 19p
Abstract
Halogenated acetonitriles and acetones are common by-products of drinking water chlorination and have been identified in reactions with model substrates. Members of both classes have been shown to be mutagenic in Salmonella, to induce sister chromatic exchange in mammalian cells and/or to interact with DNA. Such results would imply a capability for these chemicals to act as carcinogens. The present study was undertaken to determine whether the members of these classes most often found in drinking water were capable of acting as carcinogens on the mouse skin or lung. Studies included the chloro-, dichloro-, trichloro-, bromochloro- and dibromo- substituted acetonitriles. The 1,1-dichloro- and 1,1,1-trichloro- substituted acetones were tested. These data clearly show that the haloacetonitriles found in drinking water, with the possible exception of the dichloro-compound possess carcinogenic properties. To date, it has not been possible to demonstrate such activity with the chlorinated acetones. These findings emphasize the need to consider by-products other than the trihalomethanes when assessing carcinogenic hazards that are associated with alternative forms of drinking water disinfection.