Record Display for the EPA National Library Catalog

RECORD NUMBER: 76 OF 1237

OLS Field Name OLS Field Data
Main Title Behavioral Toxicity of Trihalomethane Contaminants of Drinking Water in Mice.
Author Balster, Robert L. ; Borzelleca, Joseph F. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-R-804701; EPA-600/J-81-370;
Stock Number PB83-187880
Additional Subjects Toxicology ; Trihalomethane ; Potable water ; Bioassay ; Dosage ; Mice ; Laboratory animals ; Reprints ; Drinking water ; Water pollution effects(Animals)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB83-187880 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 12p
Abstract
The behavioral toxicity of trichloromethane (TCM), dichlorobromomethane (DCBM), dibromochloromethane (DBCM) and tribromonethane (TBM) was evaluated following oral administration in mice. A variety of dosage regimens and behavioral measures were used. Studies included acute dose effect, 14- and 90-day treatments at 300 and 3000 times the estimated average human daily intake of contaminated drinking water, 30 days of 100 mg/kg/day, and 60 days of 100 and 400 mg/kg/day. In addition, TCM was tested for the production of taste aversions with 10-day administration and for behavioral teratology in offspring following extensive perinatal exposure.