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RECORD NUMBER: 71 OF 1237

OLS Field Name OLS Field Data
Main Title Augmentation of Murine Natural Killer Cell Activity by Manganese Chloride.
Author Rogers, R. ; Garner, R. ; Riddle, M. ; Luebke, R. ; Smialowicz, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83-121;
Stock Number PB84-123801
Additional Subjects Toxicology ; Cells(Biology) ; Spleen ; Mice ; Activity ; In vitro analysis ; In vivo analysis ; Reprints ; Manganese chlorides ; Cytotoxicity
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB84-123801 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 14p
Abstract
Natural Killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57B1/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels.