||Augmentation of Murine Natural Killer Cell Activity by Manganese Chloride.
Rogers, R. ;
Garner, R. ;
Riddle, M. ;
Luebke, R. ;
Smialowicz, R. ;
||Health Effects Research Lab., Research Triangle Park, NC.
In vitro analysis ;
In vivo analysis ;
Manganese chlorides ;
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Natural Killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57B1/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels.