||Cutaneous Carcinogenicity Study with Mice on the Diglycidyl Ether of 1,4-butane Diol with Attachments and Cover Letter dated 09/28/1987.
||CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
4-butane Diol (2425-79-8) ;
Chronic Toxicity ;
Toxic substances ;
Laboratory animals ;
CAS No 2425-79-8
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Dermal carcinogenicity was evaluated in groups of male and female CF1 mice (50/sex/group) receiving applications (volume not reported) of 0.05% or 0.2% (based on preliminary studies) 1,4-butanediol diglycidyl ether in acetone twice weekly to the dorsal skin for 103 weeks. Of all animals in both dose groups, 5 animals developed 6 neoplasms of the skin and subcutis; 1 control animal developed a tumor. A transient irritant reaction was observed in 37 animals with no thickening of the epidermis. A statistically significant increase in neoplasms of the treated skin was not observed.