Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 31

OLS Field Name OLS Field Data
Main Title Dose-Dependency of 2-Acetylaminofluorene Binding to Liver DNA and Hemoglobin in Mice and Rats.
Author Pereira, Michael A. ; Lin, Luan-Ho C. ; Chang, Lina W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-141;
Stock Number PB82-247503
Additional Subjects Carcinogens ; Liver ; Dosage ; Mice ; Rats ; Laboratory animals ; Deoxyribonucleic acid ; Hemoglobins ; Ingestion(Biology) ; Binding ; Nitrogen organic compounds ; Reprints ; Fluorene/acetyl-amino
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB82-247503 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract
The carcinogenic activity of 2-acetylaminofluorene (2-AAF) in mice and rats has been accurately described so that it is a suitable archetypical chemical for investigations of parameters of cross-species variation. The results of the study supported a pharmacokinetic model that related the metabolism of 2-AAF to reactive metabolites to the binding of the metabolite to DNA and hemoglobin. The results do not support a relationship of macromolecular binding to carcinogenic potency.