Record Display for the EPA National Library Catalog

RECORD NUMBER: 27 OF 31

OLS Field Name OLS Field Data
Main Title Teratology Studies with 2,4,5-Trichlorophenoxyacetic Acid and 2,3,7,8-Tetrachlorodibenzo-P-dioxin.
Author Courtney, K. Diane ; Moore., John A. ;
CORP Author National Institute of Environmental Health Sciences, Research Triangle Park, N.C.
Year Published 1971
Stock Number PB-280 005
Additional Subjects Pesticides ; Herbicides ; Toxicology ; Mice ; Rats ; Laboratory animals ; Bioassay ; Congenital abnormalities ; Dosage ; Injections(Medicine) ; Pathology ; Kidney ; Cleft palate ; Chlorine organic compounds ; Toxic substances ; Reprints ; Teratology ; Fetuses ; Dioxin/tetrachloro-dibenzo ; Acetic acid/dichlorophenoxy ; D 2-4 herbicide
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB-280 005 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract
The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were teratogenic in the CD-1, DBA/2J, and C57B1/6J strains of mice. Both compounds produced cleft palates and kidney malformations. When these compounds were administered in combination, the activity was not potentiated at the doses employed. In the CD rat, 2,4,5-T was neither teratogenic nor fetotoxic. However, TCDD produced kidney anomalies. Prenatal administration of 2,4,5-T did not affect the postnatal growth and development of the CD rat.