||Species and Strain Comparison of Acute Neurotoxic Effects of Trimethyltin in Mice and Rats.
Chang, L. W. ;
Wenger, G. R. ;
McMillan, D. E. ;
Dyer, R. S. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Central nervous system ;
Laboratory animals ;
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Pathological changes in the central nervous system in two strains of mice (BALB/c and C57BL/6) and two strains of rats as a result of trimethyltin (TMT) intoxication were compared. Both strains of mice were administered with trimethyltin chloride at a dosage of 3.0 mg TMT-C1/kg b.w. while both strains of rats were exposed to 7.5mg TMT-C1/kg b.w. Animals were sacrified at the time of development of observable neurological signs (tremor, aggression): 2 days for both strains of mice, 3 days for Long Evans (LE) rats, and 5 days for Sprague Dawley (SD) rats. It was found that there were both species and strain differences in TMT toxicity.